ABSTRACT In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120.A fluorescent KSK120 analogue was synthesized and observed to be associated with the C.trachomatis surface, suggesting that its target is bacterial.We isolated KSK120-resistant strains a
UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures
The 5-methylcytosine (5mC) modification regulates multiple cellular processes and is faithfully maintained following DNA replication.In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing protein 1 (UHRF1) plays an important role in the maintenance of 5mC levels.Loss of UHRF1 abolishes 5mC
Integrating the multiple perspectives of people and nature in place-based marine spatial planning
Abstract Marine spatial planning (MSP) has emerged as a tool to enable marine ecosystem-based management that seeks to balance human demands for ocean space with environmental protection.However, there is a history of thinking about our ocean systems as spaces, not places.As a result, most MSPs have been implemented without consideration of place.T